FREQUENCY OF NEURAL TUBE DEFECTS AMONG 1000 PREGNANT WOMEN DELIVERING AT PMC HOSPITAL NAWABSHAH.

Abstract

Introduction: Due to absence of Neural Tube closure assortment of Central Nervous system anomalies emerges, which is reasons for high dismalness and mortality in Neonates and infant considerably awful mental effect over family and incredible monetary loses. Objective: The study intended to decide the frequency of NTDs among One Thousand (1,000) ladies delivering babies in the Labor room of a Tertiary Care Hospital.Study Design: Descriptive study. Data Collection and Analysis: Study started from January 1st, 2019 to December 31st, 2019 in the Department of Obstetrics and Gynecology in relationship with Pediatrics and Neurosurgery Department. All children delivered in the labor rooms were examined for NTDs. Those determined to have NTDs were conceded into the extraordinary consideration child unit for perception and documentation. Results: Among 1000 patients, 56 women had fetuses or newborn with neural tube defects (5.6 per 1000 births). Anencephly [n=2 (4%)], Enecephlocele [n=12 (21%), meningocele / Meningomyelocele associated with hydrocephalus [n=30 (54%)] and 8 (54%) patients of Meningocele / Meningomyelocele wihtout hydrocephalus were found, spina bifida occulta [n=4(7%)], were the malformation detected. Among 56 affected NTDs, n=30(54%) were female and n=26(46%) were male. This difference is statistically significant (p<0.05). Among 56 women affected NTDs, n=6 (11%) had 13-20 years, n=40(71%) had 21-40 years while n=9 (16%) had above 40 years. Amongst the mothers with affected babies, n=26(46%) women were primiparous and n=30 (54%) women were multiparous. Determinations were made by antenatal ultrasonography half (50%) and clinically half (50%) after the birth of kids. 02 (4%) patients were smokers and 54 (96%) were non-smokers. Some patient are already taken drug such 36 (64%) patients were taken folic acid, 1 (2%) patients was taken Valporic Acid, whereas 2 (4%) patients found with other drug history. Conclusion: The prevalence of NTDs in this study is in reliable with writing and literature. Improvement in maternal nourishment and antenatal folate admission is suggested.