A RETROSPECTIVE STUDY: CORRELATION AMONG HBA1C AND SERUM LIPID PROFILE IN KARACHI’S PATIENTS OF TYPE-II DIABETES.

Abstract

Introduction: The diabetic patients have an increased tendency to develop dyslipidemia which may results to high risk of cardiovascular diseases. To study the correlation among type-II diabetic patient and the serum lipid profile to estimate the diagnostic value of HbA1c as a co-biomarker of dyslipidemia. Method: The present study was performed at Dr. Essa Laboratory & Diagnostic Centre, Karachi, Pakistan between August and October 2019. There were 491 type-II diabetic (DM-2) selected for the study (254 male and 237 female) with the mean age of 52.77 and the data was collected through review of clinical reports of patients at Bio-chemistry lab of Dr. Essa Laboratory & Diagnostic Centre. The fasting HbA1c and lipid profile (Cholesterol, Low-density lipoprotein, high- density lipoprotein, very low density lipoprotein, triglycerides and ratio of total cholesterol and triglycerides) along with their age and gender data was recorded. The correlation analysis was done by SPSS statistical package version 16.0. Result: In a total of 491 DM-2 patients 254 (51.7%) were male and 237 (48.3%) were female with a female to male ratio of 1: 1.07. Mean age was 52.77 years ± 12.6SD. Among the 491 patients 211 have >7% HaA1c and 283 had ≤ 7% HbA1c. The glycated Hba1c have significant correlation with cholesterol, triglyceride and VLDL levels and non- significant correlation of HbA1c and HDL and LDL. Conclusion: This study indicates that HbA1c has a significant correlation with parameters of lipid profile. HbA1c can be used a marker for predicting dyslipidemia and CVD in T2DM patients. We suggest regular periodic monitoring of HbA1c and lipid levels in such patients. This study adds to existing knowledge supporting correlation between HbA1c and parameters of lipid profile.