PREVALENCE OF VITAMIN-D DEFICIENCY AMONG THE PATIENTS OF HBV AND HCV RELATEDCHRONIC LIVER DISEASE.

Authors

Ali Karim1 , Shahida Hassan Memon2 , Jamil Ahmed3 , Abdul Karim Soomro4 , Abdul Manan Soomro5

KEY WORDS: Chronic Liver Disease, VD deficiency, HBV infection, VIRAL HEPATITIS C infection.

ABSTRACT

INTRODUCTION: The viral infection by HBV & HCV are commonest cause leading to acute as well

as chronic viral hepatitis. It is analysed in many studies from past era that levels of 25(OH) - D are

decreased in subjects suffering from chronic hepatic disease due to HBV and particularly HCV in

comparison to normal population. The occurrence of either insufficiency or deficiency of VD is more in

subjects suffering from chronic hepatic disease secondary to HBV & HCV. The deficiency of VD is

related with a large range of adverse effects in subjects with HBV and HCV. OBJECTIVE: research

was aimed to see occurrence of deficiency of VDD in subjects with chronic hepatic illness with HBV

and HCV. METHODLOGY: current research cross sectional type was done on blood samples of 300

subjects attending the laboratory at LUMHS Jamshoro Hyderabad, with acute or chronic HBV & HCV.

According to our research, VD levels of >30 nm/ml are considered sufficient, 14-30 ng/ml are

considered insufficient & VD levels lower 14 ng/ml are considered deficient. Hepatitis BV DNA & HBs

surface antigen blood levels validate Hepatitis B diagnosis, whereas VIRAL HEPATITIS C RNA levels

establish the diagnosis of Hepatitis C. RESULT: We received 60.3 percent men (n=181) and 39.7%

females (n=119). After serological testing, 36.1 percent of patients (n=108) tested positive for HBV

DNA, whereas 63.9 percent of patients (n=192) tested positive for VIRAL HEPATITIS CDNA.

Hepatitis B and C infections were found in 22.3 percent (n=67) of the patients. A total of 57.3 percent of

the 300 subjects were VD deficient, whereas 30.7 percent had adequate VD levels. CONCLUSION:

The findings of our investigation indicated that more than half of the patients with HBV & VIRAL

HEPATITIS C infection have VD insufficiency, which has been linked to negative clinical outcomes.

Our findings show that VD supplementation is critical in the treatment of chronic liver disorders caused

by HBC and HBV

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