ROLE OF MAGNESIUM SULFATE FOR FETAL NEUROPROTECTION IN WOMEN AT RISK OF PRETERM BIRTH.
Keywords:Keywords: MgSO4, Magnesium sulfate, Preterm labor, gestational age
Introduction: With a decrease in gestational age, the chance of cerebral palsy increases
significantly and is primarily ascribed to preterm birth. Currently, infants delivered prior to 34
weeks of gestation account for 25% of all new instances of cerebral palsy. Objective: To evaluate
the impact of MgSO4 administered to pregnant women at risk for premature delivery for fetal
neuroprotection. Materials and Methods: From January 2020 to December 2022, this
prospective observational research was carried out at obstetrics & gynecology department
hayatabad medical complex peshawar. Total 519 preterm pregnant women between 28-36 weeks
gestational age were enrolled. Out of 519, 199 premature laboring women received MgSO4 and
were placed in group A, while the remaining 320 were placed in group B because they did not
receive MgSO4. Women in group A got a 4g bolus dose of MgSO4 over 20–30 minutes, then
1g/hour. All pregnant women, whether carrying a single or multiple pregnencies, who were
between 28-36 weeks gestational age. Results: Neonatal outcomes of groups include the
following: Mechanical ventilation in group A was 45(22.6%) & 85(26.5%) in group B,
Respiratory distress 83(41.7%) vs 191(59.7%), neonatal enterocolitis 11(5.5%) vs 9(2.8%),
intensive resuscitation 6(3%) vs 12(3.7%), neonatal seizures 7(3.5%) vs 11(3.4%), NICU
admission required in group A was 85(42.7%) vs 183(57.1%) in group B, mortality in both
groups was 2(1%) vs 4(1.2%). Conclusion: The development of cerebral palsy in preterm
infants may be prevented by administering MgSO4 with a wide margin of safety. Even
though MgSO4 has only moderate benefits, it is a secure, affordable drug, so the risk-benefit
ratio favors using it.
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