COMPARISON OF MICRONIZED PROGESTERONE VERSUS NIFEDIPINE IN PREVENTION OF PRETERM LABOR.

Abstract

ABSTRACT
BACKGROUND: The definition of preterm labor is when a woman gives birth before
completing 37 weeks of gestation, which is calculated from the last menstrual cycle date
OBJECTIVE: To determine the effectiveness of micronized progesterone versus nifedipine in
the prevention of preterm labor.METHODOLOGY: A randomized controlled trial was
conducted by the Department of Obstetrics and Gynecology at Peoples University of Medical &
Health Science for Women Nawabshah during the period of September 2019 to October 2020.
Eighty-three women were treated with micronized progesterone (group 1) and 83 women were
treated with nifedipine (group 2). Nifedipine tocolysis was initiated orally. Prior to administering
the treatment, the blood pressure, pulse, uterine contractions and fetal heart rate of the mother
were assessed. Documentation was conducted every thirty minutes within the initial hour and
then hourly for up to four hours. Following this, documentation took place every four hours until
a final outcome was reached at twelve hours. RESULTS: Mean age of group 1 and group 2 was
29.01 ± 5.59 years and 28.06 ± 6.18 years, respectively. The mean parity was 2 ± 0.73 in group 1
and 2 ± 0.64 in group 2. There were 39 (46.99%) primigravida and 44 (43.01%) multigravida in
group 1 while 21 (25.30%) primigravida and 62 (74.70%) multigravida in group 2. Effectiveness
was significantly high in group 1 as compared to group 2 (77.1% vs. 57.8%; p=0.008).
CONCLUSION: It is concluded that treatment with micronized progesterone resulted in a
substantial reduction in the rate of recurrent preterm delivery among women who were at
particularly high risk for preterm delivery and reduced the likelihood of several complications in
their infants.