ASSOCIATION BETWEEN VITAMIN D LEVELS AND CHRONIC MIGRAINE: A COMPARATIVE STUDY OF DIABETIC AND NON-DIABETIC PATIENTS USING ISI AND MIDAS SCALES.

JPUMHS;2023:13:04,42-48. http://doi.org/10.46536/jpumhs/2023/13.04.469

Abstract

ABSTRACT BACKGROUND: Insulin resistance, a pivotal factor in metabolic syndrome, has emerged as a recent link to migraine development. Limited research has explored the connection between migraine and diabetes mellitus. The potential role of metabolic syndrome in linking migraine, cardiovascular disease, and obesity underscores the need to investigate the relationship between migraine and low blood vitamin D levels. OBJECTIVE: to examine the association between vitamin d levels and chronic migraine: a comparative study of diabetic and non-diabetic patients using isi and midas scales. METHODS: This was a cross-sectional study was carried out from time march to September 2022. Participants that are migraine sufferers of both genders aged 20 to 50 years were included. The patients were divided into 2 groups: Group A included diabetic migraine patients and Group B included non-diabetic migraine patients. Vitamin D levels were observed for all patients including a detailed migraine history. The MIDAS (Migraine Disability Assessment) Test was be filled for assessment of patients. The ISI (insomnia severity index) was also taken which is 7-item self-report questionnaire that evaluates the nature, intensity, and effect of insomnia. Data was analyzed through SPSS version 23. RESULTS: In this study of 173 participants, comprising 91 males and 82 females, 37 were diabetic, and 136 were non-diabetic. The primary risk factors associated with migraine were excessive screen time, stress, tea intake, and food allergies. Significant differences were observed in the prodrome and attack phases of migraine between diabetic and non-diabetic groups. Pearson correlations revealed a negative association between Vitamin D levels and the Migraine Disability Assessment (MIDAS) score (r= -.617**, p=0.0496) and a positive correlation between Insomnia Severity Index (ISI) and MIDAS score (r= .717**, p=0.0316). These findings highlight the influence of diabetes on migraine symptoms and emphasize the role of Vitamin D levels and insomnia severity in migraine-related disability. CONCLUSION: Diabetes is associated with increased susceptibility to migraine prodrome and attack phases, while non-diabetic individuals are more likely to experience moderate sleep disturbances. Furthermore, our study revealed a modest negative link between vitamin D levels and migraine-related disability (MIDAS score), as well as a positive correlation between MIDAS score and insomnia severity.