EFFECTS OF OPTIMIZED PROPORTION OF OMEGA-3 AND OMEGA-6 POLYUNSATURATED FATTY ACIDS ON BLOOD GLUCOSE LEVELS OF TYPE 2 DIABETES MELLITUS ALBINO WISTAR RATS

JPUMHS;2023:13:04,55-60. http://doi.org/10.46536/jpumhs/2023/13.04.471

Abstract

ABSTRACT OBJECTIVE: The purpose of this study was to compare the effects of consuming omega 3, omega 6, and a combination of both omega 3 and omega 6 on blood glucose levels in type 2 diabetic Wistar rats with control and diabetic control group rats. METHODOLOGY. In this investigation, n=50 male Albino Wistar rats weighing 200-250gms were employed. The animals were obtained from the Sindh Agricultural University's Animal House in Tandojam after ethical authorization to use them for testing was granted. A group of ten rats were maintained in clear-sided plastic cages and were named after the groups. RESULTS: A significant reduction was seen in the Diabetic group (Group B). Diabetes rats treated with Omega 3 and Omega 6 showed a drop in body weight, but it was smaller than the diabetes controls (Group B). However, the Omega-3 and Omega-6 combination therapy group (Group E) demonstrated the greatest results, indicating that the combination therapy greatly reduced body weight loss. CONCLUSION: The benefits of combining omega-3 and omega-6 PUFA were found to be more beneficial in avoiding HbA1C increase than -3 and -6 alone