BIOCHEMICAL EFFECTS OF LYCOPENE ON BLOOD GLUCOSE IN HIGH SUCROSE DIET FED MALE WISTER ALBINO RATS.

JPUMHS;2025:15:01,92 98.http://doi.org/10.46536/jpumhs/2025/15.01.601

Abstract

OBJECTIVE: To evaluate the Biochemical effects of lycopene on blood glucose in high
sucrose diet fed male wister albino rats. METHODS: An experimental research, spanning six
months and carried out at LUMHS Jamshoro, utilized 60 adult male Albino Wistar rats, which
were randomly assigned to four groups. Group A received 0.9% normal saline, while Group B,
serving as the positive control, was given a sucrose-rich diet with no additional treatment.
Experimental Groups C and D were administered the same sucrose diet along with lycopene at
doses of 40 mg/kg and 60 mg/kg body weight, respectively, over a 28-day period. Lycopene was
delivered daily through intragastric intubation. After the treatment phase, blood samples were
collected via cardiac puncture, and serum was separated for biochemical testing to assess blood
glucose levels. Statistical evaluation was carried out using SPSS software version 23.0.
RESULTS: After four weeks, Group A (negative control) had a mean glucose level of
135.8 mg/dL, while Group B (positive control) showed a significantly higher level of
206.8 mg/dL (P=0.0001). Lycopene-treated Groups C and D exhibited reduced glucose levels of
177.1 mg/dL and 152.4 mg/dL, respectively, showed a statistically significant decrease compared
to the positive control (P=0.0001). CONCLUSION: The study revealed that lycopene
significantly lowered serum glucose levels, suggesting its potential as a safe, accessible, cost
effective, and community-friendly natural option for managing hyperglycemia.