Aged Black Garlic Extract Improves Blood Cell Counts & Blood Lipids in Wistar Albino Rats

Abstract

Objective: The study was conducted to evaluate effects of aged black garlic extracts (ABG 1 on blood cell counts and blood lipids in Wistar albino rat model. Study Design: Experimental study Place and Duration: Isra University Hyderabad from November 2013 to May 2014. Material and Methods: Sixty adult albino rats were divided into four groups: Group I. controls received 0.9% isotonic saline, Group II. Received garlic extract orally (200 mg/kg). Group III. Received garlic extract orally (300 mg/kg) for 30 days. Blood samples were collected for hematological analysis and plasma lipids. The data was analyzed on SPSS 21.0. (IBM incorporation, USA) using one-way ANOV. Post Hoc Duncan testing was used for multiple comparisons for variables which showed significant F ratio and p-value. Ap-value of =0.05 was taken statistically significant. Results: Complete blood cell counts and blood lipids showed significant differences between the controls. and experimental garlic groups at different doses (11=0.001). The hemoglobin, packed cell volume, red and white cell counts, and platelets were raised in garlic extract groups particularly in high doses of 300mg/kg. The differential white blood cell counts also revealed significant differences. The blood lipids showed a reduction in total cholesterol_ LDL-c and a rise in HDL-c levels in ABG grOups. (p=0.001). Conclusion: The garlic extract influences hematological parameters in albino rats and reduces plasma lipids fractions which may be protective against cardiovascular disease.