Uric Acid Antioxidant in Elderly Smokers & Its Relationship with Duration & Quantity of Smoked Cigarettes

Abstract

 Objective; To determine serum uric acid anti oxidant in elderly smokers and its relationship with duration of smoking and quantity of cigarettes smoked. Study Design: Case control study Place and Duration: Department of Physiology, Isra University, Hyderabad, during June 2013-November 2014 Material and Methods: 251 cigarette smokers and 100 never smoker controls were selected through non-probability purposive sampling according to inclusion and exclusion criteria The subjects were divided into; controls and cases- the smokers. Blood samples were collected in Eppendorf tubes and processed on automated hernatoanalyzer. Uric acid was measured on Roche chemistry analyzer. The Data was analyzed on SPSS version 21.0 using one student's t test, Chi square test and Spearman's correlation. A p-value of =0.05 was taken statistically significant. Results: Mean ± SD age was noted as 57± 10.5 and 59 ± 11.5 years respectively (p = 0.91) in smokers & non smokers. Serum uric acid in smokers and controls was noted as 4.91+0.35 and 3.8+ 0.91 rrigidl respectively (p=0.0001). Serum uric acid was negatively correlated with number of cigarettes (r= 0.618, p=0.0001). Association of duration of smoking with uric acid was found to be non significant -0.26,p-0.81). Conclusion: Decreased uric acid in smokers indicates that the cigarette smoking increases the oxidative stress. Uric acid was inversely associated with number of cigarette smoked per day.