Association of Red. Cell Distribution Width and Role of Cardiac Markers in Acute Non-ST Elevated Myocardial infarction

Abstract

Objectives: To investigate the relationship between the red blood cell distribution width (RDW) and acute non-ST elevation myocardial infarction (NSTE-AMI). Study Design: Observational descriptive study Place and Duration: Pathology and Cardiology departments of Peoples University of Medical and Health Science ( PUMHS ), Nawabshah, from January to December 2015. Material and Methods: We selected 151 diagnosed patients with non-ST segment elevated acute myocardial infarction, having ages ranged between 43 and 71 years, including 91 males and 6o females admitted in cardiology department of PUMHS, on the basis of clinical history, physical examination, electro cardiogram and echo cardiographic findings. From all these patients, blood samples were collected for complete blood count, Trop t test, cardiac enzymes, blood glucose and low density lipoprotein. All the findings were recorded on a proforma designed for the study and results were statistically analyzed and tabulated. Results: The mean age was 57±14 and male to female ratio was 1.5:1. These patients were diagnosed with NSTE-AMI by positive trop-T test, ischemic ECG changes and echocardiography findings. Clinical findings in these were chest pain, dyspnea, fatigueness and ECG findings were showing ST depression with T-wave inversion while echocardiographic findings were showing partial thickness of cardiac muscle or NSTE-AMI or sub endocardial myocardial infarction. The mean value of hemoglobin was 11.5 g/d1± 1.5, total leucocyte count were I 2200/cumm ± 1200, Neutrophils 80 % 5, Lymphocytes 15 % 5, Neutrophils /Lymphocytes ratio 5.3 ± 1.1 were founded in this study. The Red cell Distributions Width percentage (with reference range of 14%) was 16.2±2.5 that were significantly correlated with above findings among the patient with non-ST elevated acute myocardial infarction. Conclusion: Higher red cell distribution width value was associated with high total leucocyte count, parentage of neutrophils, neutrophils lymphocyte ratio in patients with Non-ST elevation acute myocardial infarction.