BMI and Elevated Levels of Serum Ferritin and High Sensitivity C-Reactive Protein in Pregnant Women

Abstract

Objective: To determine the association of (CRP) and Serum ferritin with obesity and variation in its level in obese pregnant women as compared to normal weight. Methods: This comparative cross-sectional study was conducted at Physiology Department of BMSI Jinnah Postgraduate Medical Centre in Cooperation with the Department of Gynecology and Obstetrics of.linnah Hospital Karachi. 60 women of age 20 to 40 years in last trimester pregnancy were enrolled in the study with same physical parameters, placed into two equal groups' obese and normal weight. Ferritin and C - reactive protein levels of pregnant women were measured through enzyme linked immunosorbent assay (ELIZA). Results were compared and analyzed statistically. Results: The ferritin levels and acute phase protein CRP levels of obese subjects significantly higher as contrast to normal weight pregnant Women. Serum ferritin (49.8±0.76 ng /ml) VS 19.8±0.31 ng im1). C-reactive protein (9.0+0.12 mg/1 vs 4.3 ± 0.16 mg/I). The results indicate a positive correlation with BMI. Conclusion: Elevated levels of CRP and serum ferritin in over-weight gravid women were highest due to inflammation produced by body mass index (BMI).