INELIGIBILITY FOR LIVER TRANSPLANTATION IN HEPATOCELLULAR CARCINOMA.

Abstract

Introduction: HCC is common problem in pakistan. Objective: to assess the Ineligibility For Liver Transplantation In Hepatocellular Carcinoma. Methods: This descriptive case series study was conducted in the Department of Medicine Peoples University Of Medical & Health Sciences For Women Nawabshah from 1st May 2017 to 30th April 2019.One ninety eight patients were enrolled in this study.All consecutive patients diagnosed as Hepatitis B, Hepatitis C with or without cirrhosis were included.Exclusion criteria was biopsy proven secondary metastatic deposits in liver, metabolic storage disease, Wilsons Disease, Haemochromatosis. All baseline and clinical variables recorded in a structured questionnaire and the data were evaluated in Statistical Package for the Social Sciences (SPSS) version 21.0. A p value of <0.05 is considered to be statistically significant. Results: A total of 198 patients, 58.58% (n= 116) were HCV and 41.41% (n= 82) were HBV positives were included. The mean age of HBV positive patients was 39.21 ± 13.77 years while HCV positive patients were comparatively elder 47.74 ± 9.78 years. Non-eligible patients were higher in HCV group (49.13%) as compared to HBV group (32.92%). Only two parameters had shown significant association with non-eligibility of liver transplant. HBV patients with right lobe of liver involvement while HCV patients with both lobes involved and OKUDA score in both HBV and HCV groups were significantly associated with non-eligibility of liver transplantation (p <0.05). Conclusion: We have observed higher percentage of HCV patients non-eligible for liver transplantation based on the clinical grounds than HBV patients. HBV patients with right lobe of liver involvement & HCV patients with both lobes involved, and higher the OKUDA score in both HBV and HCV groups were significantly associated with non-eligibility of liver transplant (p - <0.05).