EFFECTS OF AELO VERA EXTRACT ON BLOOD SUGAR OF RABBITS: AN ANIMAL STUDY

Abstract

Objectives: To observe the effect of Aloe vera on Blood Sugar on Rabbits (animal models). Main outcome measures: Level of glucose in blood of animal models in different scheduled stages of the experiment. Materials and Methods: This Experimental (Interventional) study was conducted at department of pharmacology Pepoles University of Medical and Health Sciences, Nawabshah (SBA) from April 2019 to September 2019, after the proper approval of Research Ethical Committee of the University. This study was carried out on healthy animal models using rabbits in animal house of Gambat Medical College at Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat District KhairpurMirs’. Adult male and female rabbits ranging from 16 months to 24 months of age. Thirty healthy adult male and female rabbits were selected fulfilling the inclusion and exclusion criteria. Subjects were divided in three groups, Group-A was control group, Group-B was study group-1, served with 200mg/kg of Aloe Vera and Group-C was study group-2 and was served with 400mg/kg of Aloe Vera. Parameters such as Blood Glucose level and feed intake were evaluated at the end of experiment. The data was documented in predesigned structured questionnaire. The data was entered and analysed by using SPSS software version 25.0. Results: Blood Glucose level of rabbits showed significant reduction after thirty days of intervention compared with Control Group. Group-B served with 200mg/kg of Aloe vera showed negative correlation with control group on day 30 for both (-0.212 degree of relationship) with p value (p = 0.023). Group-C served with 400mg/kg of Aloe vera also showed negative correlation with control group on day 30 for both (-0.072 degree of relationship) with p value (p = 0.000). This shows that there is statistically significant role of Aloe vera in Glycemic control. Conclusion: It was concluded that Aloe vera has good effects in lowering Blood Glucose level of rabbits, if used regularly. Aloe vera can be used as herbal remedy with hypoglycemic drugs in pre-diabetic and diabetic patients to control