GINGER (ZINGIBER OFFICINALE ROSCOE) SUPPRESSES OBESITY AND INFLAMMATION IN FAT INDUCED WISTAR ALBINO RATS

Abstract

Objectives: To determine and compared the impact of ginger on mucosa of small intestine of normal and obese Wistar albino rats. Methodology: This animal study was conducted at the Anatomy department of PUMHSW, Nawabshah with collaboration of department of Animal Resource Center of SAU (AHVS-SAU), Tando Jam. The duration of study was 6 months from January to June 2018. Total Sixty (60) healthy male adult Wistar Albino rats (WARs) with body weight (BW) of 180.0 – 220.0 gm were selected. Rats were taken from the AHVS-SAU Tando Jam. The WARs were divided into 3-groups; 20 rats were in each group. Control group WARs were fed a normal diet, Group-B HF-diet provoked group and Group- C Ginger treated group of rich fatty diet. Animals were sacrifice as study was completed and pieces of the small intestine and were fixed in 10.0% formalin for 24 hours, and embedded in paraffin. Findings of all group animals were recorded. A pre-designed proforma was used for the collection and documentation of data during research. SPSS 22.0 was used to analyse data. Results: In present study we found significant difference declined in the body weight of WARs after consumption of ginger among groups(p<0.001). whereas histomoprholgical picture is slight different in HFD group and experimental group as compared to normal architecture of mucosa of small intestine (p<0.05). The very slightly inflammation was observed in small intestinal mucosa in HFD group as compared to control but the mucosa of small intestine of ginger consumption group almost normal (p<0.05). Conclusion: The present study concluded that ginger plays an antioxidant role on inflammation and mucosa of small intestine in obese WARs as compare to normal healthy WARs.