PREVALENCE OF HEREDITARY SPASTIC PARAPLEGIA IN ADULTS

Abstract

ABSTRACT

INTRODUCTION: The hereditary spastic paraplegia (HSP) is a condition which includes different

neurological diseases showing a genetically and heterogeneous clinically. HSP is a condition with

different types, influence the lower extremity with advancement of disease shows spasticity or

weakness, and some other symptoms of bowel and bladder dysfunctions involvement. HSP is

hereditarily heterogeneous, and in excess of 20 hereditary types have been recognized. OBJECTIVE:

The purpose of this study was to find the prevalence of hereditary spastic paraplegia in adults and

association of other symptoms of disease like bowel and bladder dysfunctions, distal muscle atrophy,

dystonia etc. METHODS: A cross-sectional observational study was conducted on 80 subjects

presenting with different neurological diseases which fall in the criteria of hereditary spastic paraplegia.

Data was collected from different hospital settings in Lahore through non-probability convenient

sampling technique. Clinical questionnaire for hereditary spastic paraplegia was used for data

collection. RESULTS: There were 43 (53.8%) male and 37 (46.3%) female patients. Total prevalence

of hereditary spastic paraplegia in adults were 3.75%. The prevalence of adult males with hereditary

spastic paraplegia were 2.50% and 1.25% in adult females. The most commonly reported symptoms in

HSP patients were distal muscle atrophy of lower limb (28.75%) and dystonia (12.5%) according to the

study. CONCLUSION: This study concluded that the total prevalence of hereditary spastic paraplegia

was very low in adults and mostly male are affected according to this study