EVALUATION OF HEMATOLOGICAL PARAMETERS IN CONFIRMED NON- STRUCTURAL-1 ANTIGEN (NS1AG) DENGUE INFECTED PATIENTS.

http://doi.org/10.46536/jpumhs/2023/13.01.380

Abstract

Abstract
Introduction: The most prevalent virus spread by mosquitoes in Pakistan is dengue virus. The high ratio
of illness to mortality caused by dengue virus infection may include clinical features ranging from mild
dengue fever to dengue shock syndrome, which may even be lethal. Objective: This study aimed to
investigate the haematological parameters in patients with confirmed Non-Structural 1 Antigen (Ns1Ag)
dengue infection. Study Design: Descriptive cross-sectional study. Place of Study: Govt. Naseerullah
Khan Babar Memorial Hospital, Peshawar. Duration of study: From September to December 2022 (Four
Months). Methods: Participants were enrolled in the current study regardless of gender after being
recruited and clinically examined by medical professionals. Immunochromatography was used to identify
Non-Structural 1 Antigen (NS1Ag) of dengue virus in all cases. Blood was drawn and processed to get a
complete blood count to study haematological parameters. The obtained data was analyzed via the
statistical programme for social sciences version 22. Results: In this study, 102 dengue-infected
individuals were recruited, with 61.8% males and 38.2% females. Haemoglobin levels were normal in
90.2% of dengue patients and decreased in 9.8%. The majority of female patients had low haemoglobin
levels. White blood cell counts were low in 26.5% of patients. Neutrophil levels were high in 67.6% of
the patients. Male patients (n=47) had more abnormal neutrophils than female patients (n=22). Low
lymphocyte levels were reported in 51% of patients, whereas high lymphocyte levels were found in
13.7% of dengue-infected patients. Low platelet levels were identified in 30.4% of individuals, with
males suffering from thrombocytopenia more than female infected with dengue virus. Conclusion: Based
on the results obtained in the current study the dengue-infected individuals had higher levels of
neutrophils, lower levels of lymphocytes, and lower levels of platelets. Also, males were seen to have
suffered more than femals. It is critical to developing diagnostic criteria based on clinical signs and
symptoms for more accurate and prompt diagnosis.