TACROLIMUS OINTMENT AS MONOTHERAPY IN MANAGEMENT OF MODERATE TO SEVEREREFRACTORY VERNAL KERATOCONJUNCTIVITIS.
Keywords:Keyword: Vernal keratoconjunctivitis, Tacrolimus,TSSS (total subjective scoring system), TOSS (total objective ocular scoring system) ASM (Associated Syestemic manifestation)
Introduction: In the modern era of industrialization and global seasonal change, human health has been
adversely affected. One of its sequels is ocular allergy. Objective: To evaluate the efficacy and
safety of (0.03%) tacrolimus skin ointment in patients with moderate to severe refractory vernal
keratoconjunctivitis (VKC). Study Design: Prospective interventional study. Setting & Duration:
Ophthalmology outpatient department (OPD) Peoples University of Medical and Health Sciences from 16
February 2019 to 16 August 2021. Material &Methods: 200 patients suffering from moderate to severe
VKC were selected, based on TSSS (Total subjective scoring system) and TOSS total objective scoring
system). The study participants were separated into 2 groups (100 each) withtreatment group
receiving0.03% Tacrolimus ointment while the other receiving conventional therapy. To determine the
effectiveness (measured by the change mostly in clinical condition), a randomised clinical investigation
was carried out and safety (safe treatment from development of any complications or side effects) of
Tacrolimus ointment in comparison with conventional therapy. Result: It was observed that 73% patients
had tarsal form of VKC, 24% had limbal and 3% had mixed (both) types of disease. Every one of the
patients had complete subjective symptom severity ratings (TSSS) and total objective ocular severity
scores (TOSS) which ranged among 2 & 3. Treatment with either 0.03% Tacrolimus or conventional
group was found to be effective in eradicating the symptoms of VKC measured by TSSS scores.
Conclusion: Among the medical therapies used in this study it is found that, Tacrolimus ointment 0.03%
was more nontoxic & actual in eradicating the severity of signs and symptoms of the vernal
keratoconjunctivitis evident by the TSSS and TOSS scores. (ASM allergic systemic
manifestations)rhinitis, asthma and eczema)
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