EFFECTS OF 25GMS/KG, 50GMS/KG AND 75GMS/KG OF BODY WEIGHTS OF GARCINIA CAMBOGIA PLANTS ON BLOOD GLUCOSE LEVELS OF DIABETIC RATS----AN ANIMAL MODEL STUDY.

Abstract

ABSTRACT
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) affects an estimated 462 million people
worldwide, accounting for roughly 6.28% of the world's population. OBJECTIVE: The study is
aimed to determine the potential effects of alternative medicine in the management of T2DM as
many medicinal plants and its product have traditionally been used since ancient time and one
such medicine plant is Garnicia Cambogia that belongs to the family Clusiaceae widely known
as Malabar Tamarind. Hence, the present study is aimed to determine the effects of ancient
medicine approach by using Garnicia Cambogia plant extract in the management of T2DM in
animal model. METHODOLOGY: A total number of n=100 Wistar rats were divided into five
groups. Rats were procured from the Basic Medical Sciences Institute's Open Market/Animal
House at JPMC Karachi. While housing and handling the rats, the researchers scrupulously
adhered to the rules established in the NIH Guide for the Care and Use of Laboratory Animals.
RESULTS: The negligible P-value (P = 0.57) supports this conclusion, demonstrating that there
was no significant variation in body weight between the rat groups. The fact that the rat groups
had equal baseline body weights eliminates any study bias and allows for a more accurate
comparison and interpretation of the experimental data. CONCLUSION: The study suggests
that Garcinia Cambogia plant extract has favourable benefits on blood glucose levels and
glycemic control in an animal model of type 2 diabetes, especially at higher dosages.