EFFECTS OF ANTIPSYCHOTIC DRUGS ALONE VERSUS ANTIPSYCHOTIC DRUGS IN COMBINATION WITH VITAMIN D AND VITAMIN E ON LIPID PROFILE LEVELS OF PSYCHIATRIC DISORDER PATIENTS-----A RANDOMIZED CONTROLLED TRIAL.

Abstract

ABSTRACT
BACKGROUND: A psychological disorder poses a greater risk of all-cause of deaths at earlier
stages of life1
. According to epidemiological research, people with mental illnesses have a 7 to
24 year lower life expectancy, which is a bigger toll than heavy smoking. METHODOLOGY:
The study had comprised of n=140 individuals who had mental problems and were deficient in
both vitamin D and vitamin E. All individuals had been taking antipsychotic drugs on a
consistent basis for at least two months previous to the commencement of the research, and their
antipsychotic doses remained constant throughout the study. RESULTS: The analyses of the
findings had revealed that participants in the Risperidone group had substantially higher levels of
Total Cholesterol after antidepressant administration (235.26±35.37 vs. 157.09±16.34 mg/dL;
p<0.0001). When compared to other treatment groups, the mean value of Total Cholesterol was
considerably lower (p<0.05) in the group receiving Quetiapine coupled with Vitamin E and
Vitamin D. Regarding efficacy, the treatment groups receiving Olanzapine, Risperidone,
Quetiapine, Olanzapine combined with Vitamin E and Vitamin D, and Risperidone combined
with Vitamin E and Vitamin D did not show any significant effects on the Total Cholesterol
levels of patients (208.06±34.32 vs. 229.31±37.59 vs. 178.86±25.23 vs. 178.11±20.72 mg/dL,
respectively). CONCLUSION: In conclusion, the study's findings demonstrated that risperidone
usage was related with higher levels of total cholesterol and lower levels of high-density
lipoprotein (HDL) compared to the control group. When quetiapine was coupled with vitamins E
and D, total cholesterol and low-density lipoprotein (LDL) levels were significantly reduced.
Furthermore, when individuals in the risperidone group were given with vitamin E and vitamin
D, their triglyceride levels were lower