REACTIVATION OF HEPATITIS B VIRUS AFTER COVID-19 VACCINATION.

Abstract

Abstract

ABSTRACT
This case presents a possible vaccine adverse event of reactivation (recurrence) of a dormant
hepatitis B infection in a young female patient reported after administering the first dose of
Pfizer-BioNTech COVID-19 vaccine. This case aims to explore a potential adverse reaction of
COVID-19 mRNA vaccine which can reboot the inactive viruses, in this case of hepatitis B
infection, due to immunomodulation leading to decreased alloreactivity after vaccination, as no
other trigger or cause was found. A young female with history of inactive hepatitis B infection
was admitted in the emergency ward of our Hospital with vomiting, fever, and jaundice after
receiving the first dose of Pfizer-BioNTech (NY, NY, USA & Mainz, GY) COVID-19 vaccine.
Her blood tests confirmed the resurgence of the acute hepatitis B virus infection and accordingly
treated with antiviral Tenofovir and other appropriate supportive management. After clinical
improvement and regression of liver function test, she was discharged from the hospital.