C-REACTIVE PROTIEN AS A PROGNOSTIC INDICATOR FOR ISCHEMIC STROKE OUTCOMES.

http://doi.org/10.46536/jpumhs/2023/13.03.447

Abstract

OBJECTIVES: To evaluate the value of CRP levels and their possible role in the pathogenesis of

acute ischemic stroke.PATIENTS AND METHODS: This descriptive study was conducted at the

medical wards of Liaquat University Hospital, Jamshoro, Hyderabad. Patients of either sex with their

first-ever ischemic stroke were included. Blood samples were taken from all patients to measure the

serum C-reactive protein. Blood samples were taken within 24 hours after an ischemic stroke, within

48 to 72 hours, and at hospital discharge. Relationship of C-reactive protein at different stages after

acute ischemic stroke and also its role in the pathogenesis of acute ischemic stroke.RESULTS: A total

of 100 patients with ischemic stroke were evaluated for CRP levels. There were 72 men and 28 women.

65% of patients had raised CRP levels at the time of admission within 12 to 24 hours after stroke,

while 35% had a normal 0.5 mg/dl CRP level at the time of admission. Out of 65% of patients, the

level of CRP persistently rose until discharge in 46% of patients, while the level dropped to normal in

the remaining 19% of patients. Higher CRP levels at the time of admission were associated with large

infarct sizes. Deaths were also observed in patients with a CRP level greater than 1.5mg/dl within 12

to 24 hours of stroke.Conclusion: CRP observed to be the helpful tool for assessing the prognosis of

ischemic stroke patients. This is attributed to its capability to signify the systemic inflammatory

response within the body, and its consistent link with unfavorable outcomes.