EFFECT OF POLYUNSATURATED FATTY ACIDS PUFA ON LIPID PROFILE AND GLUCOSE LEVEL AMONG ALLOXAN – INDUCED TYPE – II DIABETES MALE ALBINO RATS

JPUMHS;2023:13:04,61-66. http://doi.org/10.46536/jpumhs/2023/13.04.472

Abstract

ABSTRACT OBJECTIVE The purpose of this study was to determine the effect of polyunsaturated fatty acids on lipid profile and glucose level among alloxan induced diabetes male albino rats.METHODOLOGY: A total 50 male albino rats of Wister strain, weighing from 200 to 250 grams were taken for this experimental study. All the rats were procured from the animal husbandry of Sindh Agricultural University, Tandojam. They were maintained on balanced laboratory – based diet. The rats were also kept in 12 hour light- and 12 hour dark cycle. Water was freely given. All the rats were divided in five respective groups, named as control group-A, Diabetic control group-B and experimental group-C, D and E. Each group contained 10 rats and were kept in separate cages.RESULT: Mean fasting blood glucose in different group before induction showed insignificant difference among the group p=0.996. Mean triglyceride showed significant findings with p<0.001 in different groups showed insignificant findings with p=0.128 whereas mean level of LDL showed insignificant results among the group with p+0.961. CONCLUSION: The present study showed beneficial results of omega 3 fatty acids and omega 6 fatty acids when administered in combination (ratio of 1:1) on dyslipidaemia caused by insulin resistance in type II diabetes mellitus.