EXPLORING THE LINK BETWEEN OXIDATIVE STRESS AND DIABETES: BIOCHEMICAL INSIGHTS

http://doi.org/10.46536/jpumhs/2024/14.02.515

Abstract

BACKGROUND: The study was aimed to evaluate the link between Oxidative Stress and diabetes and to
determine the possible levels of antioxidant enzymes and levels of gene expression between control and diabetic
induced male albino wistar rats. METHODOLOGY: Diabetes was induced by injecting single low-dose
streptozotocin along with providing high fats diets in the experimental group whereas in the control group standard
feeding protocol was employed. The analyses of the outcome measures were performed twice at baseline and after
6 weeks of intervention. RESULTS: Diabetic group had shown higher levels of gene expression of an oxidative
damage marker, indicating increased OS and cellular damage. The discoveries uncovered that the outflow of
qualities encoding cell reinforcement catalysts was downregulated in the diabetic gathering, demonstrating a
misfortune in cancer prevention agent safeguard. These outcomes gives proof at the degree of sub-atomic
pathways that make sense of diabetes' irregularity between cell reinforcement safeguards and oxidative harm,
stressing the basic job of operating system in illness movement. CONCLUSION: Taking everything into account,
the research center based exploratory review utilizing a creature model of diabetes has given new data on the
association among operating system and diabetes mellitus. The discoveries feature operating system's essential
capability in the beginning and movement of diabetes, particularly when cell reinforcement safeguard components
are powerless. The intricate link between OS and diabetes inflammation is made clear by the fact that diabetics
have downregulated genes for antioxidant enzymes and increased inflammatory markers.