THE RELATIONSHIP BETWEEN VISCERAL ADIPOSITY, HEMATOLOGICAL PARAMETERS, AND GLUCOSE PARAMETERS IN NON-DIABETIC ADULT MALES.

http://doi.org/10.46536/jpumhs/2024/14.02.521

Abstract

BACKGROUND: Visceral obesity, which is defined as extra adipose tissue accumulation around organs
present in the abdominal cavity is also called central/abdominal obesity and glucose parameters with visceral
adiposity among obese/non-obese healthy adult males aged between 30-50 years. METHODS: A total of
118 adult males took part in this case-control study by the random selection method, Visceral obesity was
obtained by the BIA method, and body composition was assessed by WHR (waist to hip ratio), and BMI
(body mass index). Hematological parameters including complete cell count, hemoglobin & derivatives,
glycemic parameters serum HbA1c and Random blood sugar were done. This study used independent t-tests,
chi-square testing, Pearson correlation, and regression analysis, with an alpha threshold of 0.05 being
considered significant. RESULTS: Comparative hematological parameters between obese and non-obese
show great diversity, mean hemoglobin in the obese group is 14.37 ± 1.0, and in the non-obese is 15.1 ± 1.48
along with significant variation in hemoglobin derivatives and RBC count In Leukocyte count mean
neutrophils which are 59.08 ± 8.11 shows the significant difference when compared with an opposite group
which is 55.52 ± 7.77. Hb is negatively correlated with visceral obesity in the control group (P = 0.03, r =
0.19) HCT (P = .006, r = - 0.2511), RBC, MCV, MCH, and MCHC were also negatively correlated. Among
White blood cells neutrophils and lymphocytes were positively correlated with VA (P = 0.54, r = 0.05),
Platelet (P =0.61, r =-0.046), and erythrocyte sedimentation rate (P = 0.0165, r =0.2204). A significant
positive correlation was also shown between Hba1c with visceral obesity, (P = .0001, r = 0.51). In regression
analysis, the similarly negative coefficients -.048, -.223, -.118, and -18812.9 for Hb, HCT, MCH, and PLT
show that these blood measurements fall as visceral fat levels rise and increased visceral fat positively
predicted increased HbA1c with coefficient 0.61. CONCLUSION: Increased visceral fat regardless of age
can lead to disturbed blood parameters and impairment in glucose metabolism in non-diabetic apparently
healthy adults. The study's limitations, however, are the limited sample size and potential confounding
variables that were not considered.