EFFECT OF GARCINIA CAMBOGIA ON HISTOPATHOLOGICAL OUTCOMES OF PANCREATIC CELLS IN ALLOXAN INDUCED DIABETIC ALBINO RAT.

http://doi.org/10.46536/jpumhs/2024/14.02.523

Abstract

BACKGROUND: Diabetes mellitus, is a prevalent metabolic condition categorized by
continual hyperglycemia due to either impaired insulin secretion or resistance, has a high
prevalence across Southeast Asia—most notably in Pakistan. As such nations work fervently
to control the disorder, scientists have begun exploring the potential of Garcinia cambogia
extract to help regulate blood sugar levels. OBJECTIVE: In this investigation, researchers
concentrated on GcE's impacts on pancreatic β-cell mass and islet morphology in diabetic rats
highlighting the need for further research in alternative therapies for DM. METHODS The
investigation was designed as a pre-clinical experiment carried out over a twelve month
duration at the Department of Pharmacology and Therapeutics, Basic Medical Sciences
Institute, Jinnah Postgraduate Medical Centre, Karachi. A total of sixty young male albino
Wistar rats were split into three sets which were induced to develop diabetes using Alloxan.
The animals received differing doses of extracts derived from Garcinia cambogia termed GcE
across an eight week timeframe. At the end of the defined experimental interval, the rats were
anesthetized, sacrificed, and blood specimens were drawn to quantify fasting serum insulin
levels under sedation. RESULTS: The mean weight significantly increased in Group C with a
mean value of 304.95±35.15 gm as compared to group A and B with mean value of
292.05±43.15 gm and 294±50.16 gm respectively. Group C showed a significant increase in β
cell mass (355±55 units) compared to Groups A (280±35 units) and B (275±40 units), with
improved islet shape (p<0.005). CONCLUSION: The study concludes that Garcinia cambogia
extract shows promise in enhancing pancreatic β-cell mass and islet morphology in diabetes,
suggesting potential therapeutic benefits.